On Thursday, September 12, 2019, Biohackers Toronto held a detailed talk on the benefits of NAD+. Our presenter, Duane Hewitt is a molecular biologist who has a twenty year career in the biotechnology and pharmaceutical industry.
From the talk, our members learned about the benefits of NAD+ (called the molecule of youth) and how it can help you feel vital, healthy and young. We learned a lot during this educational night of fun and also enjoyed networking with like-minded health enthusiasts!
As a member of Biohackers Toronto, you are part of a global organization of Biohacker Meetups in 30+ cities around the world. As a part of the global collective, attendees to this event received a ⭑FREE⭑ intranasal spray bottle of pure NAD+ ($75 CAD value), courtesy of our wonderful sponsor, Alive By Nature.
What is Biohacking?
Biohacking is the art and science of taking control of your own biology. It involves changing the environment inside and around you to achieve the biological outcomes you want, so you can perform at any level you want. Connect in real life with the world’s largest biohacking community!
What is NAD+ and What are its Benefits?
Nicotinamide adenine dinucleotide, or NAD, is a coenzyme found in every cell of our bodies. NAD is crucial to the basic reactions in all of our cells that keep us alive.
The Sinclair Lab at Harvard Medical School discovered that NAD+ levels decline with age. The Lab continues to study the mechanisms by which the NAD+ level affects DNA repair and looks for therapeutic targets to improve this process.
NAD+ may help with the following:
- Autoimmune conditions 
- Increased exercise capacity and reversal of vascular aging 
- Neurodegenerative diseases such as Alzheimer’s, Parkinson’s and prion diseases 
- Traumatic brain injuries 
Episode 6 of Long Long Life (below) characterizes NAD+ as the fuel for proteins that repair DNA. This episode is en français, with English subtitles.
Biohackers Toronto is a community of health nerds who get together to learn more about health topics and share our biohacking experiences. We are the Toronto Chapter of Biohackers Collective, which is a decentralized network of autonomous chapters, exploring interesting health topics and holding educational and social events around the world.
 Tullius, S., Biefer, H., Li, S. et al. NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun 5, 5101 (2014). https://doi.org/10.1038/ncomms6101
 Das, A., Huang, G., Bonkowski, M. et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell Volume 173, Issue 1 (2018). https://doi.org/10.1016/j.cell.2018.02.008
 Zhou M, Ottenberg G, Sferrazza GF, Hubbs C, Fallahi M, Rumbaugh G, Brantley AF, Lasmézas CI. Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment. Brain. 2015 Apr;138(Pt 4):992-1008. doi: 10.1093/brain/awv002. Epub 2015 Feb 11. PMID: 25678560; PMCID: PMC4840455.
 Won SJ, Choi BY, Yoo BH, Sohn M, Ying W, Swanson RA, Suh SW. Prevention of traumatic brain injury-induced neuron death by intranasal delivery of nicotinamide adenine dinucleotide. J Neurotrauma. 2012 May 1;29(7):1401-9. doi: 10.1089/neu.2011.2228. Epub 2012 Apr 17. PMID: 22352983; PMCID: PMC5972775.
The first version of this post was published to our private meetup group on Wednesday, August 28, 2019. The updated version was first published here on May 13, 2023 and updated on May 26, 2023.